TMEM106C is overexpressed and modulates cell mobility in metastatic colon cancer cells

Colon cancer is the third most commonly diagnosed in men worldwide. grows slowly and metastasis has already occurred after diagnosis. Therefore, new targets are needed colon treatment Transmembrane proteins (TMEM) play a critical role presents different expression profile variety of tumor cells. TMEM106C TMEM family protein, but its on development unknown. In this study, we aimed to investigate gene metastatic level was tested by western blot, qRT-PCR immunofluorescence methods. order test effect cells, been knockdown with shRNA technology. addition, cell invasion, migration adhesion assays were performed clarify whether characters. Ford first time, showed overexpressed carcinoma Moreover, demonstrated that migration, invasion capabilities reduced silenced Furthermore, observed morphology changed upon knockdown. conclusion, important for